Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
نویسندگان
چکیده
منابع مشابه
Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
In this review, we discuss insights gained through the use of stem cell preparations regarding the modeling of neurological diseases, the need for aging neurons derived from pluripotent stem cells to further advance the study of late-onset adult neurological diseases, and the extent to which mechanisms linked to the mismanagement of reactive oxygen species (ROS). The context of these issues can...
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15 صفحه اولMicroglia-aging: roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging.
The accumulation of lysosome- and mitochondria-derived reactive oxygen species (ROS) are the most important causative factors for aging. Autophagic dysfunction and mitochondrial DNA damage in the central nervous system (CNS) are prominently found in microglia, the resident mononuclear phagocyte population within the CNS. The autophagic dysfunction may induce the defective turnover of mitochondr...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2014
ISSN: 1663-4365
DOI: 10.3389/fnagi.2014.00292